About four years ago I wrote about the PC competition in the conversation about Two-Spirit people among Native Americans. I still agree with much of it, but I was too dismissive of the idea. There actually are sources that describe men who wished to live as women among some of the New World tribes, and in some cases, they were people of high status who were believed to have understanding of the spirit world. In other cases, they were tolerated by held in lower esteem. I only read about half of it, enough to see that I had been wrong. The topic doesn't interest me that greatly. Some of you might find it more worth your while in contemplating the nature of humankind.
Some things to note: the practice seems to have been limited to men taking on the roles of women. Women who might want to take on men's roles were likely not encouraged in this; while sexual relations with men were often a part of this status, a more general taking on the role of a woman is the point - it is not men living as couples, but something more transgender; some contemporary sources claim the custom was limited to certain tribes they had seen. I did not see any northeastern tribes in the mix, and those are the ones I am more familiar with. The article is a translation from the French, and stresses contact with the tribes around the Great Lakes and Mississippi River. I don't know if that is significant.