From October 2008: Just so that people know, this is not a popular med combination. It tends to be tried when other strategies have failed. And neither Remeron not Effexor are all that popular singly, never mind together. Still, there is something to be said for a shotgun effect that hits a lot of different receptors. Folks swear by it.
California rocket fuel a combo of Remeron and Effexor which can give a triple boost to the serotonin system, a double boost to the norephinephrine system, and a single boost to the dopamine system.
This combo has an all-or-nothing reputation in the biz, when it has any reputation at all. Many psychiatrist have never heard of it by this slangy term. The "nothing" being all side effects and little mood improvement. But it's a combination some folks have had great relief from if the Effexor wasn't doing it for them. It is also very cool to say - the sort of medicine that makes you think "Gee, I wish I was depressed so I could try that."