The FDA approved a non-opioid painkiller. Journavx, developed by Vertex Pharmaceuticals, targets a protein called the NaV1.8 voltage-gated sodium channel, which transmits pain signals from sensory neurons to the brain. No other drugs on the market target this protein; existing painkillers instead bind to several other different NaV channels at once. In a phase 3 trial with 2,000 patients undergoing surgery, Journavx reduced pain as effectively as hydrocodone plus paracetamol and had fewer side effects. It also does not appear to be addictive. But the drug will cost about $233 per week; opioids cost about $12 per week. (From Works in Progress)
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